YouGottaPractice on Instagram: "Explanation: • A. ❌ CIN – Associated with APC mutations, not MLH1. • B. ✅ MSI – Loss of MLH1 → mismatch repair defect → hallmark of MSI. • C. ❌ CIMP – Involves promoter methylation, can silence MLH1 but MSI is the actual phenotype. • D. ❌ p53 – Late event in adenoma-carcinoma sequence, unrelated to MLH1 loss."