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Chronic Kidney Disease (CKD) Stage 4. Stage 4 chronic kidney disease is an advanced stage of kidney disease. At this stage, the kidneys have lost a significant amount of their ability to filter waste and excess fluid from the blood. The condition requires close medical supervision to protect remaining kidney function and prepare for possible future treatment needs. 1. What happens in Stage 4 kidney disease?disease? eGFR: Usually 15–29 mL/min/1.73 m². Waste buildup: Waste products may accumulate
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