Mar 21, 2023 · H3K27me3 is a downstream target of the polycomb repressive complex 2 (PRC2), which has histone methlyltransferase activity; epigenetic modification of histone H3 results in H3K27me3 …

Apr 14, 2022 · H3K27me3: H3 K27-altered tumors show loss of H3K27me3 staining, a finding that by itself is not specific, however, may be helpful in identifying diffuse midline gliomas with H3 p.K28I …

Sep 13, 2021 · Synovial sarcoma is a malignant soft tissue tumor of uncertain histogenesis with variable epithelial differentiation.

Jan 20, 2021 · Negative stains Loss of nuclear H3K27me3 in high grade sporadic and radiation associated tumors Sensitivity is lower in low grade and NF1 associated MPNST (complete loss in …

Oct 31, 2023 · CNS tumor - Meningioma is the most common primary CNS tumor, arising from arachnoid cap cells associated with dura mater or choroid plexus, accounting for 36% all CNS tumors

Soft tissue stains: AE1 / AE3 ALK1 BCOR beta catenin caldesmon CAMTA1 CCNB3 (pending) CD31 CD34 CD99 CDK4 D2-40 DDIT3 (pending) desmin DOG1 DUX4 EBER EMA ERG ETV4 (pending) …

Dec 3, 2024 · Ependymoma is a neuroepithelial tumor with ependymal differentiation that most commonly has ventricular involvement and arises in the cerebrum and spinal cord

Sep 24, 2024 · Proliferative nodule is a distinct cellular nodule of benign melanocytes that is found within and arises from a benign background nevus (typically congenital).

Nov 5, 2020 · Myoepithelioma, myoepithelial carcinoma and mixed tumor of soft tissue are a group of uncommon neoplasms that share morphological, immunophenotypic and genetic features with their …

Mar 19, 2025 · Angiosarcoma is a malignant vascular neoplasm, which may arise in previously irradiated skin or breast tissue (secondary postradiation angiosarcoma) or in nonirradiated tissue (primary …