Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune …

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is majorly expressed in activated T cells and works as a critical regulator in the inflammatory response.

Oct 10, 2025 · CTLA-4 is a promising target for immune checkpoint inhibition in cancer therapy, with CTLA-4 blockade achieving prolonged overall survival for responding patients.

Mar 1, 2020 · We present recent advances in CTLA-4 in regulating T-cell tolerance and autoimmunity. The structure and expression of CTLA-4, its mediated signaling and role in autoimmunity reviewed. …

A protein found on T cells (a type of immune cell) that helps keep the body’s immune responses in check. When CTLA-4 is bound to another protein called B7, it helps keep T cells from killing other …

Jul 22, 2025 · CTLA-4, or Cytotoxic T-lymphocyte-associated protein 4, is a protein receptor found on the surface of T-cells. T-cells are specialized white blood cells, key components of the immune …

Aug 1, 2024 · Anti-cancer or immunotherapy drugs called immune checkpoint inhibitors are designed to prevent T-cells from partnering with proteins that turn them off. One type of immunotherapy drug that …