Clooney and Wyle, who played Doug Ross and John Carter, respectively, starred alongside each other on the hit medical drama for five seasons before Clooney exited the series to focus on other acting endeavors. Wyle continued with the show through season 11, making guest appearances in seasons 12 and 15. ER ran from 1994 to 2009.

Clooney and Wyle spent several years as fan-favorite characters Doug Ross and John Carter on ER, which ran for 15 seasons between 1994 and 2009. While Clooney left during the fifth season, Wyle was a main cast member through season 11. Both returned for additional episodes throughout the show's run.