The Red Sox recalled the speedy David Hamilton from Triple-A to take Mayer's spot on the roster. Hamilton saw action in 62 games for Boston before he was sent down, where he hit .179 (going 22-for-123) with three doubles and three home runs. On the base paths, he was successful on 15 of his 18 stolen base attempts.

In 2021, the Boston Red Sox owned the No. 4 overall pick in the MLB draft, the highest pick the organization possessed since 1967. The club used that coveted selection on the player who was rated the top prospect in that draft class by MLB Pipeline — Chula Vista, California, prep shortstop Marcelo Mayer.