We present in this paper general formulas for deriving the maximum likelihood estimates and the asymptotic variance-covariance matrix of the positions and effects of quantitative trait loci (QTLs) in ...

We model a covariance matrix in terms of its corresponding standard deviations and correlation matrix. We discuss two general modeling situations where this approach is useful: shrinkage estimation of ...

Alternatively, you can directly specify the matrix A to find the D-optimal design when A is the variance-covariance matrix for the runs. You can specify the data set containing the covariance matrix ...