Clooney and Wyle, who played Doug Ross and John Carter, respectively, starred alongside each other on the hit medical drama for five seasons before Clooney exited the series to focus on other acting endeavors. Wyle continued with the show through season 11, making guest appearances in seasons 12 and 15. ER ran from 1994 to 2009.

Clooney and Wyle starred together on the first five seasons of 'ER' as Doug Ross and John Carter respectivelyNEED TO KNOWGeorge Clooney shared his opinion about his fellow ER alum Noah Wyle's new show,