The FDA recently approved mepolizumab for treating adults with inadequately controlled COPD and an eosinophilic phenotype, ...

A distinct inflammatory profile marked by neutrophil activity and cytokine elevation may underline poor biological response ...

Mepolizumab, a humanized monoclonal antibody, reduces eosinophil counts in blood and tissues by blocking interleukin-5, a key eosinophil cytokine, through binding to eosinophil surface receptors ...

With mepolizumab vs. placebo, patients with COPD and type 2 inflammation experienced significantly fewer moderate/severe exacerbations in a year, according to results published in The New England ...

Mepolizumab is a fully humanized, anti–interleukin-5 monoclonal immunoglobulin G1 antibody with a half-life of approximately 19 days; it does not fix complement. 13,14 By binding to free ...

The phase 3 MATINEE trial (NCT04133909) provided additional context for where mepolizumab may be most useful. 2 This trial randomized 804 patients with a history of frequent exacerbations and ...

Mepolizumab is the only approved biologic evaluated in patients with an eosinophilic phenotype characterized by a blood eosinophil count (BEC) threshold as low as ≥150 cells/µL. 1,2 BEC is ...

Mepolizumab, a humanized monoclonal antibody that targets interleukin-5 (IL-5), significantly reduced COPD exacerbations in patients with COPD regardless of the history or severity of ...

Mepolizumab is currently being investigated for severe hypereosinophilic syndrome, nasal polyposis and COPD. In the US, Nucala (100mg fixed dose subcutaneous injection of mepolizumab ...

Mepolizumab was found to significantly reduce exacerbations in adults with chronic obstructive pulmonary disease (COPD), according to results from the MATINEE trial.

Mepolizumab, sold as Nucala, was not compared fairly against other asthma treatments, raising questions as to whether it has benefits over other drugs already used for the condition, ...

Mepolizumab (), an interleukin-5 antagonist, is currently approved for use as an add-on maintenance treatment for patients with severe asthma with an eosinophilic phenotype.It is also indicated in ...