Testing mice for depression is challenging. “You can’t put a mouse on a psychiatrist’s couch and ask it how it’s feeling,” said Sarah Bailey, who heads the pharmacology group at the University of Bath ...

Preclinical studies of the serotonin 2A (5-HT2A) antagonist deramciclane suggested an anxiolytic profile, which has not been unequivocally established in the clinic. The same receptor profile also ...

In the Forced Swim Test (FST), a mouse or rat is placed in a closed container of water from which they cannot escape. The animal initially struggles to escape but eventually gives up and begins ...

Animal models of human disease have extremely mixed results, and all too often they do not work well and accomplish their goals of helping humans. 1 One such procedure, the forced swim test, is a ...