The spindle assembly factors HURP (hepatoma up-regulated protein), NuSAP (nucleolar and spindle-associated protein) and TPX2 (targeting protein for XKLP2) associate with microtubules to recruit ...
Bipolar spindle assembly requires a balance of forces where kinesin-5 produces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein. Accordingly, Kinesin-5 ...
Scientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, ...
This is a preview. Log in through your library . Abstract The spindle midzone, a conspicuous network of antiparallel interdigitating nonkinetochore microtubules between separating chromosomes, plays a ...
Robert Blackwell, Christopher Edelmaier, Oliver Sweezy-Schindler, Adam Lamson, Zachary Gergely, Eileen O’Toole, Ammon Crapo, Loren Hough, J. Richard McIntosh ...
DLGAP5 is proposed as a causal gene related to oocyte meiosis disorder for the first time. It expanded the current spectrum of pathogenic genes responsible for the phenotype of oocyte maturation and ...
A new theory could explain how spindles have defied previous attempts at modeling their movement. A researcher collaboration including the Flatiron Institute’s Center for Computational Biology (CCB; ...
Berlin, Germany: Abnormalities in the spindles (the bi-polar thread like structures that link and pull the chromosomes during cell division) of human embryos before implantation may be the primary ...
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