Mutation-induced drug resistance is a significant challenge to the clinical treatment of many diseases, as structural changes in proteins can diminish drug efficacy. Understanding how mutations affect ...

Many HER2-positive breast cancer (BC) patients relapse within a year of HER2-targeted therapy. Here, we identify pathogenic mutations in HER2 dimerization domains II and IV (DDMs) as a critical ...

This is a molecular surface diagram of the three-dimensional structure of type 2 wild poliovirus strain Lansing viewed from the outside of the virion [25]. A pentameric unit is represented. The virus ...

Influenza A virus hemagglutinin trimer is depicted in cartoon form, with monomers colored, green, blue and wheat. The bottom of the trimer would be attached to virions. Sialic acids bound to the HA ...