CRISPR safety check evaluates intended and unintended mutations

A team of researchers led by Professor Akitsu Hotta (Department of Clinical Application) developed a comprehensive framework ...
ascopubs.org

NGS-based molecular panel analysis of metastatic prostate cancer for daily routine: How often do we detect druggable mutations?

Assessment of PARP1 mRNA expression as prognostic of aggressive pathology and adverse outcomes, and as predictor of response to PARP inhibition in castration-sensitive prostate cancer. Association of ...
Medical Xpress

Menopausal hormone therapy may not pose breast cancer risk for women with BRCA mutations, analysis suggests

Using menopausal hormone therapy (MHT) was not associated with an increased risk of breast cancer in women with inherited mutations in the BRCA1 or BRCA2 genes, according to the results of a matched ...
Medical Xpress

Structural analysis shows Alzheimer's disease mutation produces 'cottonwool' structures in the brain

An international collaboration led by RIKEN researchers has discovered how unusual spherical structures form in the brains of people with a mutation that causes a form of inherited Alzheimer's disease ...
EurekAlert!

Proteogenomic analysis of healthy and cancerous prostate tissues using SILAC and mutation databases

Missense mutations influence protein abundance in prostate cancer. Using a SILAC-based quantitative proteomics approach, we identified significant proteomic differences between healthy and tumor ...
ascopubs.org

Swiss-PO 2025: Advancing Cancer Mutation and Structural Analysis for Precision Oncology With the Latest Release

Impact of Germline BRCA Mutation Status on Antitumor Activity of Modified FOLFIRINOX in Patients With Advanced Pancreatic Cancer: An Exploratory Analysis Swiss-PO was expanded and redesigned to ...