Epithelial development, maintenance and repair requires that cells can divide and adapt to complex cell shape changes without dissociating their contacts with neighbouring cells and, hence, that they ...

The molecular machinery that propels cell division consists of parts that are, by now, fairly familiar. How the parts work together, generating and transmitting power as needed, is less clear. To see ...

We have studied cytoskeletal architectures of isolated mitotic apparatus from sea urchin eggs using quick-freeze, deep-etch electron microscopy. This method revealed the existence of an extensive ...

Adam R. Lamson, Christopher Edelmaier, Matthew A. Glaser, and Meredith D. Betterton (2019). Biophysical Journal116, 1719. bioRxiv DOI: 10.1101/419135. DOI: 10.1016/j ...

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the ...

Scientists have gained new insight into the formation of the spindle, which is the molecular machine that divides up genetic material prior to cell division. Their work focuses on the motor protein, ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

RanGAP1 was the first documented substrate for conjugation with the ubiquitin-like protein SUMO-1. However, the functional significance of this conjugation has not been fully clarified. We sought to ...

Spindle microtubules are yellow, with actin cytoskeletal filaments blue in this mitotic spindle. There is fresh recognition that cells' ability to build the structures that carry out cell division: ...

For a new plant to grow from a seed, cells need to divide numerous times. Daughter cells can each take on different tasks and sometimes vary in size. How plants determine the plane of cell division in ...

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Yet, there are currently no highly effective therapies to treat patients with GBM and ~90% patients die within 2 years of ...