The regulation of neuronal excitability and the maintenance of an appropriate balance between excitation and inhibition are central to brain function. Inhibitory synaptic transmission, predominantly ...
A holistic inquiry into how toxic tau impacts synapses provides a new take on the processes that lead to neuronal dysfunction ...
A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...
Transcriptional dysregulation in Huntington’s disease (HD) causes functional deficits in striatal neurons. Here, we performed Patch-sequencing (Patch-seq) in an in vitro HD model to investigate the ...
Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...
An analysis of how synaptic proteins change during early development reveals differences between mice and marmosets but also what's different in individuals with autism spectrum disorders. The ...
Craniopharyngioma, a benign yet highly invasive tumor occurring along the hypothalamus-pituitary axis, presents a unique clinical challenge. Although nonmalignant, its proximity to critical brain ...
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