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RAS-MAPK inhibition halts spinal deformity in neurofibromatosis type 1 mouse model
Spinal deformities such as scoliosis and kyphosis are among the most serious complications of neurofibromatosis type 1 (NF1), a genetic disorder that affects about one in 3,000 people.
Immuneering is set to progress its lead oncology candidate, atebimetinib, to the next stage of clinical development in both first-line pancreatic and non-small cell lung cancer (NSCLC). In ...
Mitogen-Activated Protein Kinase (MAPK) signalling cascades are fundamental to the regulation of numerous cellular processes, including stress response, inflammation, cell cycle control and apoptosis.
NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...
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