Lysosomes require tight regulation of their pH to degrade their contents. Researchers know that V-ATPase pumps protons into these little digestive sacs, but what protein shuttles the ions back out?

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes. Lysosomes ...

Researchers found that the body’s natural recycling system, the lysosome, plays a vital role in removing the protein that ...

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes. An organelle is a small structure in a cell that is ...

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. A lysosomal storage disorder, mucolipidosis type II causes edema of the internal ...

Lysosomes are the garbage disposals of animal cells. As the resources are limited in cells, organic materials are broken down and recycled a lot -- and that's what lysosomes do. Detecting problems ...

CHICAGO (CBS) -- Lysosomes – membrane-bound structures within each cell of humans and all animals – are sometimes known as the cells' "garbage disposals" or "cellular janitors." The structures are ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 45 (November 5, 2019), pp. 22619-22623 (5 pages) Contacts between the endoplasmic reticulum (ER) and ...

Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications on how the targeted suppression of lysosome function may lead to brain cancer therapy.

In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, and their bones grow malformed. In a rare disease called mucolipidosis type II, people's hearts and abdomens swell, ...