Obesity associated with hypothalamic dysfunction was initially described in patients with craniopharyngioma. Hypothalamic obesity may also result from brain radiation, infection (eg, tuberculosis), ...

The prevalence of obesity is steadily rising and has huge health and financial implications for society. Weight gain is due to an imbalance between dietary intake and energy expenditure and research ...

Hypothalamic obesity (HyOb) develops when damage to the hypothalamus — from brain tumors, traumatic brain injury, radiation therapy, or stroke — disrupts how your body regulates appetite and ...

FDA approval establishes setmelanotide as the first labeled option for acquired hypothalamic obesity, addressing a population estimated at ~10,000 in the US and characterized by severe hyperphagia.