Glucocorticoids act on target cells via two isoforms of intracellular glucocorticoid receptors (GRs) called GRα (hormone-binding form) and GRβ which does not bind any glucocorticoids. A cycle of Hsp90 ...

Glucocorticoid drugs are used widely. However, their long-term use is limited by severe side effects, including high blood levels of glucose, fatty liver, and type 2 diabetes. New research now shows ...

ABBV-154, an antibody-drug conjugate comprising adalimumab conjugated to a proprietary glucocorticoid receptor modulator, shows potential for extending flare-free periods in patients with ...

Clinical next generation sequencing (NGS) of fine needle aspiration (FNA) biopsies in non-small cell lung (NSCLC) and pancreatic cancers. This is an ASCO Meeting Abstract from the 2013 ASCO Annual ...

Berlin, Germany - The glucocorticoids provide treatment efficacy equaled by few other drug classes, but at a price in side effects that many patients are loathe to pay. While new drugs such as the TNF ...

Epidural glucocorticoid injection is an intervention commonly used for managing lumbosacral radicular pain. The goal of the injection is to administer glucocorticoids to the epidural space to reduce ...

The investigators of this study compared outcomes between patients who had eosinophilic or noneosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP) by comparing the influence of body mass ...

Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. We performed a randomized, double-placebo, double-blind clinical ...

Both renal response and low disease activity independently predicted earlier glucocorticoid discontinuation in patients with lupus nephritis. A 10-year prospective study identified predictors and ...

Please provide your email address to receive an email when new articles are posted on . Providers should educate patients when prescribing glucocorticoid therapy. Tapering off glucocorticoids should ...