It has been 65 years since the scurfy mutation arose spontaneously in mice at the Oak Ridge National Laboratory in the United States, and it is 13 years since the molecular cloning of the forkhead box ...

Regulatory T cells are specialized immune cells that suppress the immune response and prevent the body from attacking its own cells. Understanding how these cells work is key to determining how they ...

Differentiation of multipotent precursor cells into distinct cell lineages is orchestrated by integration of cell-extrinsic cues, such as recognition of soluble or cell-bound ligands, growth factors, ...

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is caused by a missense mutation in the FOXP3 forkhead domain. Panel A shows normal frequencies of FOXP3-expressing ...

The protein Foxp3 is vital to the function of immune cells called regulatory T cells, which control immune system activation. Despite its importance, how Foxp3 regulates the immune system using ...

Thanks to regulatory T cells (Tregs), the immune system is kept in line via a careful system of checks and balances. Immune response too light? A viral infection spreads throughout the body. Immune ...

In this issue of Journal of Clinical Oncology, Merlo et al 8 suggest that FOXP3 is expressed in breast cancer cells, and the expression level is associated with patient survival. Using ...

Scientists at the Salk Institute say they have discovered that the Foxp3 protein is essential for creating the unique chromatin architecture of regulatory T cells and, in turn, promoting their immune ...

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...

TBCRC009: A multicenter phase II study of cisplatin or carboplatin for metastatic triple-negative breast cancer and evaluation of p63/p73 as a biomarker of response. Background: Predictive markers of ...

Researchers determined the Foxp3 protein is actually a cofactor, hijacking DNA-binding proteins responding to the immunological environment of the T cell. Based on the type of response needed, ...

Yongqiang Feng, PhD, St. Jude Department of Immunology, investigated the role Foxp3 plays in regulatory T cell function, demonstrating that the protein likely acts as a transcription cofactor, ...