A new artificial intelligence-powered tool can help researchers determine how well an enzyme fits with a desired target, helping them find the best enzyme and substrate combination for applications ...

Enzymes are thought to have evolved highly specific catalytic activities from promiscuous ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we found that 37% of its ...

To boost crops more efficiently in the future, the evolutionary past may hold key insights. The way that plants process ...

Nitrilases are a unique class of enzymes that catalyse the hydrolysis of nitrile compounds to yield the corresponding carboxylic acids or amides. Their application in biotransformation processes has ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 10 (Mar. 10, 2009), pp. 3764-3769 (6 pages) We report a computational, structure-based redesign of the ...

The Carbohydrate-Active enZYme (CAZymes) classification system is a database that contains the knowledge of enzymes that are involved in the formation and break down of complex carbohydrates and ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research. The γ-secretase enzyme is capable of cleaving ...