A hallmark of type 2 diabetes is the progressive loss of beta cell mass: cells in the pancreas that produce and release ...

High concentrations of free fatty acid (FFA) in ketotic dairy cows activate endoplasmic reticulum (ER) stress pathways, ...

A hallmark of Type 2 diabetes is the progressive loss of beta cell mass: cells in the pancreas that produce and release ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of ...

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a new ...

Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system produce an enormous amount of plasma membrane during the myelination process, making them particularly ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...

Misfolded proteins cause intracellular stress, which induces the unfolded-protein response (UPR). The UPR is a three-pronged signalling pathway that induces genes which cause cells to acquire a ...

The synthesis of proteins in the cell is a key process of life. By this means, the genetic code of the genome is translated into the amino acid sequence of proteins. The process is complex – and has ...