In a recent study published in Nature Biotechnology, researchers developed a whole-genome sequencing (WGS) method that read four canonical deoxyribonucleic acid (DNA) bases, viz., adenine (A), ...
Cytosine and adenine base editors (CBEs and ABEs) are promising new tools for achieving the precise genetic changes required for disease treatment and trait improvement. However, genome-wide and ...
Cytosine and adenosine base editors (CBEs and ABEs) are integral to molecular breeding, enable precise modification of single-nucleotide polymorphisms (SNPs) in plants, which are crucial for agronomic ...
This is a preview. Log in through your library . Abstract The mechanism of DNA cytosine-5-methylation catalyzed by the bacterial M.Hhal enzyme has been considered as a stepwise nucleophilic addition ...
DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...
Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...
DNA methylation is an important epigenetic process where a methyl group is added to the cytosine or guanine nucleotides in the genome. DNA methyltransferases represent the key enzymes in such ...
It’s time to turn to sequencing the epigenome, the DNA modifications that alter gene expression and determine our individual genetic identity. DNA molecule with methylation on the center cytosine ...
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