Faithful replication of the genome is essential for development, tissue homeostasis and prevention of malignancy. Key steps in eukaryotic DNA replication include the licensing of replication origins, ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

The precise temporal control of DNA replication and the coordinated activation of repair pathways are fundamental to genome stability. Eukaryotic chromosomes replicate in a defined programme during S ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...

Johnson and Alistar competed as finalists in CU Boulder’s 2025 Lab Venture Challenge where their technology generated much interest from industry leaders. Access to DNA is crucial in many branches of ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

A new study has uncovered a hidden step that helps the deadliest malaria parasite survive and multiply inside the human body. Researchers studying Plasmodium falciparum found that the parasite relies ...

New research has revealed a connection between ancient viral DNA embedded in the human genome and the genetic risk for two major diseases that affect the central nervous system. New research from King ...