Mutant superoxide dismutase 1 (SOD1) has been linked to one-fifth of inherited cases of amyotrophic lateral sclerosis (ALS), where its misfolded form appears to damage motor neurons. But SOD1 does not ...

Erlotinib Plus Gemcitabine Compared With Gemcitabine Alone in Patients With Advanced Pancreatic Cancer: A Phase III Trial of the National Cancer Institute of Canada Clinical Trials Group We evaluated ...

A familial form of ALS is caused by mutations in the superoxide dismutase (SOD1) gene. A new paper shows that mutant SOD1 binds chromogranins in secretory vesicles and that its release promotes ...

A recent paper posted to the Public Library of Science (PLOS) ONE journal showed that plasma levels of chromogranin A (CgA) could predict death in coronavirus disease 2019 (COVID-19) patients. CgA, a ...

Panel A shows soluble-core proteins in bovine chromaffin vesicles after two-dimensional sodium dodecyl sulfate–polyacrylamide gel electrophoresis, followed by Coomassie blue staining. DBH denotes ...

Researchers at UC San Diego and Weill Cornell Medicine have used artificial intelligence to identify a 40-gene signature linked to resilience against Alzheimer’s symptoms, centering on a protein ...

To the Editor: Taupenot et al. mention the accumulation of chromogranin A in the preamyloid plaques of Alzheimer's disease and its activation of brain microglial cells, leading to neuronal ...