The molecule called CD44 is a transmembrane glycoprotein involved in cell to cell adhesion, interactions, and signaling. It is also a receptor of hyaluronic acid (HA) which is mechanistically involved ...
CD44 is observed in ureteric bud structures and is implicated in branching morphogenesis during early mouse renal development. Healthy adult kidney demonstrates minimal CD44, but CD44 is up-regulated ...
Due to their rapid metastatic spread, pancreatic tumors are among the most aggressive types of cancer. Only three to five percent of patients have a survival rate of five years. A team of researchers ...
Surprising findings from a study in The American Journal of Pathology show that mice with a CD44 protein deficiency stay lean, despite being on a high-fat diet Researchers investigating the role of ...
Protein biosignature identified by LC-MS/MS in classifying breast cancer and predicting tumor response to neoadjuvant therapy. Methods: Histological analysis of the breast was carried out on mounted ...
One of the main obstacles to successfully treating breast cancer is the cells' ability to change in ways that make them resistant to treatment. Understanding the cellular mechanisms that mediate this ...
Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. Adjuvant cyclophosphamide, methotrexate, and fluorouracil versus fluorouracil, ...
Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity. A ...
Studies in mice and humans show fibroblasts that overexpress HAS2 develop an aggressive phenotype. Scientists have implicated an interplay between overexpression of hyaluronan synthase 2 (HAS2) and ...
A group of researchers from the University of Seville and the Seville Biomedicine Institute (Instituto de Biomedicina de Sevilla - IBiS) has published a study in which they determine that a protein ...
Hyaluronan is a polyanionic, megadalton-scale polysaccharide, which initiates cell signaling by interacting with several receptor proteins including CD44 involved in cell-cell interactions and cell ...
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