In patients greater than age 65, more than 90% of aortic stenosis involves trileaflet valves which have developed heavy calcification. [5] In these instances the calcium deposits are thought to alter ...

(Boston)—Calcific aortic valve disease (CAVD) is the major heart valve disease that afflicts nearly 10 million patients globally with an annual mortality exceeding 100,000, and the numbers continue to ...

The MarketWatch News Department was not involved in the creation of this content. Results presented in oral session demonstrated that treatment with ataciguat reduced aortic valve calcium and improved ...

The human body has sophisticated defenses against the deposition of calcium minerals that stiffen heart tissues, researchers at the University of Illinois Urbana-Champaign and collaborators at UCLA ...

Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) has been previously linked to several chronic inflammatory disorders and it has been established that PTPN22 regulates T-cell receptor ...

Transcatheter aortic valve replacement (TAVR) demonstrated better short-term outcomes, while surgical aortic valve replacement (SAVR) had better long-term outcomes. A recent study found that when it ...

Researchers have now proposed a molecular mechanism that links amyloid deposition in the aortic valve with degenerative calcification. They also theorize that other risk factors for CAVD, such as high ...

Aortic stenosis is a disease often diagnosed in its asymptomatic phase due to its distinct murmur and the widespread use of noninvasive imaging. The history, however, is still of paramount importance ...

Kardigan Presents Positive Phase 2 Data on Ataciguat in Patients With Moderate Calcific Aortic Valve Stenosis at American Heart Association Scientific Sessions 2025 Results presented in oral session ...