In the latest 2025 NFL mock draft for ESPN, the San Francisco 49ers have a clear direction in which they want to head. ESPN’s Matt Miller shared his latest two-round mock draft following the Senior Bowl and Shrine Bowl all-star events. It has the 49ers looking to the trenches for help.

Matt Miller goes two rounds deep in his latest mock draft. Who rose after the Senior Bowl? Which QBs will be early picks?

NFL mock drafts have the Seattle Seahawks addressing the offensive line early. That's the baseline expectation, considering the Seahawks have massive needs across the interior of their O-line, and arguably at right guard as well.